Depending on the source, vitamin C may contain other ingredients that can interact negatively with CBD oil. shows unknown or no data on negative interactions between CBD and Vitamin C. Even though there are no reported interactions directly between only Vitamin C and CBD, some sources of Vitamin C might be less effective and contribute to a potential negative reaction.

Below, we’ll look at a few sources of vitamin C that may negatively interact with CBD oil. 

A few Vitamin C distinctions are synthetic ascorbic acid isolate and natural whole food Vitamin C complex. Most Vitamin C added to products are purified synthetic ascorbic acid isolate powder.

Does CBD Oil Have Vitamin C In It?

No. Even though some CBD manufacturers can add various ingredients, only a handful of CBD companies put Vitamin C in their products. 

CBD (cannabidiol) is a different molecule than Vitamin C.

Most CBD products with added Vitamin C used synthetic ascorbic acid powder.

Below, we’ll take a look at the difference between synthetic ascorbic acid and vitamin C from natural whole foods.

Vitamin C (ascorbic acid) & CBD interaction with other drugs

Vitamin C (as ascorbic acid) interacts with 27 different types of drugs with minor or moderate severity.

There are also four disease interactions with Vitamin C. If you’re on dialysis, hemolysis, have kidney stones, or are on a sodium restricted diet — Vitamin C might have a negative interaction requiring caution.

A rare side effect in taking high doses of ascorbic, requiring immediate medical attention, is if you experience pain in your lower back or on the side.

Lesser common side effects of taking higher doses of Vitamin C as ascorbic acid are diarrhea, dizziness, faintness, flushing, reddish skin, headache, mild increase of urination, nausea, vomiting, or stomach cramps.

In excessively high doses of ascorbic acid, over a long period of time, can produce conditional scurvy.

CBD can also interact with several potential drugs.

If you’re taking medication, consult with your primary healthcare provider to make sure it’s safe to add Vitamin C and CBD.

Synthetic Ascorbic Acid Vs Natural Whole Food Vitamin C

What Is Ascorbic Acid?

In 1920, ascorbic acid was discovered by Albert Von Szent Györgyi

The FDA legally enforces that ascorbic acid can be called vitamin C.

Vitamin C was first isolated in 1933 from fresh fruits, vegetables, and the adrenal cortex.

Originally, the isolated form of vitamin C was called Hexuronic Acid and was later renamed to its modern title of ascorbic acid for its anti-scurvy properties.

Is Ascorbic Acid The Same As Vitamin C?

According to the peer-reviewed journal Nutrients, ascorbic acid is the reduced form of Vitamin C.

Ascorbic acid is a single ascorbate ion molecule and isn’t the complete form of the entire vitamin C complex.

Instead, ascorbic acid is a small part of the entire vitamin C matrix.

The full matrix of the vitamin C complex is not accurately “just” ascorbic acid.

Rather vitamin C contains a grid-like network of entangled groups, sections, and gradients that make up the complete vitamin C nutrient.

Whole food vitamin C “complex” contains an array of other micronutrients and phytochemicals, such as bioflavonoids, carotenoids phenolics, and anthocyanins.

Difference Between Ascorbic Acid And Vitamin C 

Depending on the study design, there’s either no difference between synthetic vitamin C or there are differences

Vitamin C doesn’t operate or work in isolation, whereas the pure vitamin C isolate ascorbic acid molecule does act without the rest of the vitamin C family.

Ascorbic acid requires the use of other nuts and bolts to perform the basic functions of proper activity and slow down the entire vitamin C complex from breaking down or degrading.

The entire vitamin C family also has to include:

  • Vitamin P
  • Rutin
  • Bioflavonoids
  • Factor K
  • Factor J
  • Factor P
  • Tyrosinase (enzyme)
  • Ascorbinogen
  • Mineral co-factors
  • And numerous others

Without any of the above listed components of vitamin C, there is no properly functioning activity and no complete vitamin operation.

Vitamin P, in more detail, are polyphenols. 

A more accurate way to describe vitamin C is as a verb, not a noun. Vitamin C is more of a complex moving action requiring multiple activities and interactions to properly function.

What this all means is when you see the ingredient — ascorbic acid — on a food label, it’s actually the one molecule and nothing else.

(Summary) What exactly is ascorbic acid actually?

  • Ascorbic acid is only the outer shell (wrapper) protecting the other pieces of the full vitamin C matrix
  • Ascorbic acid is only one molecule of the vast vitamin C community
  • Vitamin C requires countless other components to actually function
  • Vitamin C is an action activity, not a single stationary component

Is Synthetic Vitamin C As Good As The Natural Vitamin?

To start, a critical question begins with — what are the measurements researchers are utilizing to determine what it means for synthetic chemicals to be “as good” as natural whole food nutrients?

The journal Nutrients dives deep into one specific measurement of bioavailability.

Bioavailability is how much of the nutrients actually gets absorbed and put to work by the body.

Researchers in this study compare the differences of bioavailability between synthetic and natural vitamin C.

What they found was the bioavailability of synthetic vitamin C is relatively similar to vitamin C from whole fruits.

Even though the bioavailability of synthetic and natural vitamin C might be very similar, what other measurements determine which is better for long term health?

Other studies show there are differences in the movement of vitamin C throughout the body, it’s distribution, metabolism, and excretion.

In the Nutrient journal, the researchers make a quick mention that the differences are “likely” to have minimal in how it impacts the physiology — normal function of the human body. 

The journal concludes by verifying vitamin C taken from a whole food is considerably better due to the inclusion of the 33+ other nutrients contributing to health.

As usually, the research says conflicting and opposing statements about vitamin C from food and vitamin C from supplements.

Some studies state dietary vitamin C offers more protective properties, while other studies show a reduction in certain incidents of disease.

Because vitamin C is present in the food supply, it’s challenging for researchers to perform accurate studies to verify which is actually better, based upon the measurements of certain endpoints.

How plants and whole foods naturally create Vitamin C (ascorbic acid).

According to peer reviewed journal Nature, ascorbic acid is biosynthesized (in plants) via a complex conversion mechanism.

Through this complex biosynthetic pathway, the plant produces several different types of naturally occurring ascorbic acid.

Different types of naturally occurring ascorbic acids include:

  • L-Ascorbate
  • D-Erythrosacobate
  • D-Erythorbate
  • D-Araboascorbate